CTSC:multicenter101410

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Agenda

1. establishment of the first virtual trial

Multicenter Clinical Trail Working group Meeting Minutes October 14, 2010

In attendance:

• Valerie Humblet
• Bob Lenkinski
• Clare Tempany
• Charles Guttmann
• Simon Warfield

Modalities to start with: CT and MRI, protocol without contrast Bodypart: neuroimaging, there is already a common neuro protocol for pediatric MS. Example: 3 sites, 3 MRI scanners 3T: 1 GE, 1 Philips and 1 Siemens: Implement common protocol with human phantoms take the dataset and look for reproducibility for 3 outcome measures; total brain volume, CFS and white/gray matter. understand where protocols are equivalent and different. Need to understand intra- and inter- variability Test difference obtained with different version of same software