Difference between revisions of "Projects:LesionSegmentation"

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Back to [[Algorithm:Utah2|Utah 2 Algorithms]]
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Back to [[Algorithm:Utah2|Utah 2 Algorithms]]
 
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= Lesion Segmentation =
 
= Lesion Segmentation =
  
Quantification, analysis and display of brain pathology such as white matter lesions as observed in MRI is important for diagnosis, monitoring of disease progression, improved understanding of pathological processes and for developing new therapies. The Utah Neuroimage Analysis Group develops new methodology for extraction of brain lesions from volumetric MRI scans and for characterization of lesion patterns over time. The images show white matter lesions (yellow) displayed with ventricles (blue) and transparent brain surface in a patient with an autoimmune disease (lupus). Lesions in white matter and possible correlations with cognitive deficits are also studied in patients with multiple sclerosis (MS), chronic depression, Alzheimer’s disease (AD) and in older persons.
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= Description =
  
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Quantification, analysis and display of brain pathology such as white matter lesions as observed in MRI is important for diagnosis, monitoring of disease progression, improved understanding of pathological processes and for developing new therapies. Utah Center for Neuroimage Analysis develops new methodology for extraction of brain lesions from volumetric MRI scans and for characterization of lesion patterns over time. The images show white matter lesions (yellow) displayed with ventricles (blue) and transparent brain surface in a patient with an autoimmune disease (lupus). Lesions in white matter and possible correlations with cognitive deficits are also studied in patients with multiple sclerosis (MS), chronic depression, Alzheimer’s disease (AD) and in older persons.
|[[Image:prastawa-lupus-demo001.png|thumb|256px|Segmentation of a lupus case with large lesions]]
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|[[Image:prastawa-lupus-case001-3T.png|thumb|256px|Segmentation of a 3T lupus case with small lesions]]
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<center>
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{| border="0" style="background:transparent;"
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|[[Image:prastawa-lupus-demo001.png|thumb|256px|Segmentation of a lupus case with large lesions.]]
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|[[Image:prastawa-lupus-case001-3T.png|thumb|256px|Segmentation of a 3T lupus case with small lesions.]]
 
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= Publications =
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In addition to the identification of the location and shape of lesions in 3D, we are interested in analyzing the longitudinal series of brain MRI showing lesions. For this purpose, we have developed a method for estimating a physical model for lesion formation. The model that we use is an approximation using a reaction-diffusion process that is based on expected diffusion properties (as observed through DTI). This approach gives a richer parametrization of lesion changes in addition to volume and location, as the model estimation provides descriptions of growth and spread for individual lesions. In the future, we plan to incorporate this approach for analyzing lesion MRI of a subject over time by characterizing the change patterns through the physical model parameters.
  
* Marcel Prastawa and Guido Gerig. Brain Lesion Segmentation through Physical Model Estimation. International Symposium on Visual Computing (ISVC) 2008. Lecture Notes in Computer Science (LNCS) 5358, Pages 562-571.
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[[Image:prastawa-lesionest.png|thumb|center|400px|An example of the lesion model formation estimation result. Starting from an initial guess of the reaction-diffusion process, the method estimates a model that best fits the observed data. Left: initial guess. Center: final estimate. Right: observed patient data. Top row: the T2 intensities, bottom row: lesion probabilities]]
* Marcel Prastawa and Guido Gerig. Automatic MS Lesion Segmentation by Outlier Detection and Information Theoretic Region Partitioning. 3D Segmentation in the Clinic: A Grand Challenge II Workshop at Medical Image Computing and Computer Assisted Intervention (MICCAI) 2008. Insight Journal.
 
  
 
= Key Investigators =
 
= Key Investigators =
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*Clinical Collaborators
 
*Clinical Collaborators
 
**MIND: Jeremy Bockholt, Mark Scully
 
**MIND: Jeremy Bockholt, Mark Scully
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= Publications =
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''In Print''
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* [http://www.na-mic.org/publications/pages/display?search=LesionSegmentation&submit=Search&words=all&title=checked&keywords=checked&authors=checked&abstract=checked&sponsors=checked&searchbytag=checked| NA-MIC Publications Database on Lesion Segmentation]

Latest revision as of 20:30, 11 May 2010

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Lesion Segmentation

Description

Quantification, analysis and display of brain pathology such as white matter lesions as observed in MRI is important for diagnosis, monitoring of disease progression, improved understanding of pathological processes and for developing new therapies. Utah Center for Neuroimage Analysis develops new methodology for extraction of brain lesions from volumetric MRI scans and for characterization of lesion patterns over time. The images show white matter lesions (yellow) displayed with ventricles (blue) and transparent brain surface in a patient with an autoimmune disease (lupus). Lesions in white matter and possible correlations with cognitive deficits are also studied in patients with multiple sclerosis (MS), chronic depression, Alzheimer’s disease (AD) and in older persons.

Segmentation of a lupus case with large lesions.
Segmentation of a 3T lupus case with small lesions.

In addition to the identification of the location and shape of lesions in 3D, we are interested in analyzing the longitudinal series of brain MRI showing lesions. For this purpose, we have developed a method for estimating a physical model for lesion formation. The model that we use is an approximation using a reaction-diffusion process that is based on expected diffusion properties (as observed through DTI). This approach gives a richer parametrization of lesion changes in addition to volume and location, as the model estimation provides descriptions of growth and spread for individual lesions. In the future, we plan to incorporate this approach for analyzing lesion MRI of a subject over time by characterizing the change patterns through the physical model parameters.

An example of the lesion model formation estimation result. Starting from an initial guess of the reaction-diffusion process, the method estimates a model that best fits the observed data. Left: initial guess. Center: final estimate. Right: observed patient data. Top row: the T2 intensities, bottom row: lesion probabilities

Key Investigators

  • Utah Algorithms: Marcel Prastawa, Guido Gerig
  • Clinical Collaborators
    • MIND: Jeremy Bockholt, Mark Scully

Publications

In Print