Projects:RegistrationLibrary:RegLib C14

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Slicer Registration Use Case Exampe #14: Intra-subject Brain PET-MRI with MRI orientation adjustment

this is the fixed reference image. All images are aligned into this space lleft this is the moving image. The transform is calculated by matching this to the reference image LEGEND

lleft this indicates the reference image that is fixed and does not move. All other images are aligned into this space and resolution
lleft this indicates the moving image that determines the registration transform.

lleft brain MRI lleft PET
MRI: coronal T1w
256 x 256 x 79
0.86 x 0.86 x 2.5 mm
PET: axial, fluorodeoxyglucose
128 x 128 x 35
4.29 x 4.29 x 4.25 mm

Objective / Background

Image fusion.

Keywords

PET-MRI, brain, intra-subject, image fusion

Input Data

  • Button red fixed white.jpgreference/fixed : baseline MRI: 0.97 x 0.97 x 3.27 mm , PET: 4.7 x 4.7 x 3.3 mm
  • Button blue tag white.jpg moving: PET: 4.1 x 4.1 x 5 mm

Registration Results

Download

Link to User Guide: How to Load/Save Registration Parameter Presets


Discussion: Registration Challenges

  • the original DICOM files of the MRI have image orientation data stripped. Hence the volume does not load in correct orientation and needs to be adjusted
  • the two series have different voxel sizes
  • image content is very different in the PET

Discussion: Key Strategies

  • we use the Volumes module to adjust the MRI voxel size based on the info in the DICOM header
  • we use the Transforms module to reorient the MRI along the proper axes
  • Register Images is used to automatically align the PET with the MRI