2012 Winter Project Week:GeometricMetamorphosisTBI

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Geometric Metamorphosis for TBI

Key Investigators

  • Kitware: Danielle Pace, Stephen Aylward
  • UNC: Marc Niethammer
  • Utah: Marcel Prastawa
  • UCLA: Andrei Irimia, Jack van Horn


  • Image registration of longitudinal neuroimaging data of traumatic brain injury (TBI), with the aim of predicting long term outcome and designing treatment plans.
  • The geometric metamorphosis registration algorithm jointly estimates global background deformations and local pathology changes. This allows injury changes to be analysed without the impact of background motion.

Approach, Plan

  • Continue validation studies in simulated and actual image data.
  • Meet together to discuss next steps.


  • Project discussions between Danielle, Stephen and Jack.
  • Data discussions between Danielle and Marcel.
  • Group discussion on TBI project identified requests from algorithm developers to DBP and clarified clinical realities.

Delivery Mechanism

This work will be delivered to the NA-MIC Kit as a Slicer extension.


Marc Niethammer, Gabriel L. Hart, Danielle F. Pace, Paul M. Vespa, Andrei Irimia, John D. Van Horn, and Stephen R. Aylward, Geometric Metamorphosis, MICCAI 2011.