Difference between revisions of "2013 Project Week:Imaging Genetic for Stroke"

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Image:PW-SLC2013.png|[[2013_Winter_Project_Week#Projects|Projects List]]
 
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Image:WMH_T1.png‎| T1 images in stroke dataset.
 
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Image:WMHseg.png | left: FLAIR images, middle: manual delineation of 'interesting' areas, right: manual WMH segmentation.
 
 
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<h3>Objective</h3>
 
<h3>Objective</h3>
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We want to expand and explore a imaging genetics model developed in our lab for (potentially continuous) phenotypes in stroke patients. Combined with the [[2013 Winter Project Week:WMH Segmentation|WMH Segmentation]]
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We want to explore a imaging genetics model and identify (potentially continuous) phenotypes in stroke patients. Combined with the [[2013_Project_Week:WMH_Segmentation_for_Stroke|WMH segmentation]], we will start with WMH-based imaging phenotypes.
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We are developing methods for segmentation of white matter hyperintensity in FLAIR images of stroke patients. Specifically, WMH is to be localized in particular areas of the brain, as seen in a training set. This dataset is particularly challenging due to the low resolution (1mm x 1mm x 7mm) and with cropped fields of view in the given images.
 
 
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<h3>Approach, Plan</h3>
 
<h3>Approach, Plan</h3>
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* Find and apply appropriate registration method to register cropped, low resolution T1 scans
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* Run through the WMH pipeline.
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* Register T1 scans to FLAIR images with rigid registration
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* Construct distribution map of WMH  
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* Create mask of relevant areas for WMH segmentation from manual segmentations
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* Explore clustering of WMH
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* Investigate several known methods for segmentation of WMH segmentation using training images.
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* Explore current imaging genetics model developed in our lab with above phenotypes and stroke dataset genotypes.
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* Write thorough pipline for above steps.  
 
 
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Revision as of 19:03, 3 January 2013

Home < 2013 Project Week:Imaging Genetic for Stroke


Key Investigators

  • Adrian Dalca, Kayhan Batmanghelich, Polina Golland, MIT
  • Natalia Rost, Jonathan Rosand, MGH

Project Description

Objective

We want to explore a imaging genetics model and identify (potentially continuous) phenotypes in stroke patients. Combined with the WMH segmentation, we will start with WMH-based imaging phenotypes.

Approach, Plan

  • Run through the WMH pipeline.
  • Construct distribution map of WMH
  • Explore clustering of WMH
  • Explore current imaging genetics model developed in our lab with above phenotypes and stroke dataset genotypes.

Progress

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