2013 Project Week:4DShapeAnalysis

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  Projects List

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  Shape evolution of sub-cortical structures. Color denotes magnitude of velocity.

Key Investigators

• James Fishbaugh, Marcel Prastawa, Guido Gerig, SCI
• Hans Johnson, Iowa

Project Description

Objective

In past project weeks, we have explored the application of shape regression to study sub-cortical changes associated with Huntington's disease. This has led to the development and release of open source shape analysis software. During this project week, we would like to investigate a new algorithm recently developed for our software. The method is the extension of linear regression to shapes, where we jointly estimate a baseline shape (intercept) and initial momenta vectors (slope) which define the dynamics of shape change over time. This is in contrast to the current implementation, which assumes the baseline shape is fixed at the earliest time point.

Approach, Plan

• Individual regression with control points at shared locations
  • Compare to previous results
  • Compare differences between HD subjects and controls

Progress

HD Subjects

10001

Shape evolution of sub-cortical structures for subject 10001. Color denotes magnitude of velocity.