4D DTI analysis via longitudinal modeling of tract diffusivities

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Key Investigators

Anuja Sharma, Bo Wang, Andrei Irimia, Micah Chambers, Jack Van Horn, Marcel Prastawa, Guido Gerig

Project Description

Objective

  • Preliminary longitudinal evaluation of white matter diffusion changes along specific tracts in TBI subjects.
  • Collaborate with the UCLA team to evaluate results and discuss improvements.

Approach, Plan

  • Patient specific co-registration of acute and chronic DTI images.
  • ROI based white matter tract extraction
  • Assembling diffusion properties along tract in a space normalized fashion via a consistent mapping of tract geometry across timepoints.
  • Modeling of diffusion changes along time by utilizing the complete cross-sectional distribution of diffusion values along tract.

Progress

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