2013 Summer Project Week:Landmark Registration

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Key Investigators

  • MGH: Greg Sharp, Nadya Shusharina, Paolo Zaffino
  • Isomics: Steve Pieper
  • MD Anderson Cancer Center: Erol Yeniaras


Develop and refine a module for hybrid manual/automated linear and nonlinear registration.

Approach, Plan

  • Review features and implementation of the current prototype code
    • Landmark/fiducial management
    • Visualization modes
    • Linear registration
  • Discuss/plan/implement new features
    • Integrate hybrid registration tool (uses landmarks and image intensities)


  • Reviewed interface with research and clinical potential users to get valuable usage feedback - Linear mode seems very useful
    • hotkeys for zoom
    • better color/glyph for fiducials
  • Reviewed status of plastimatch nonlinear module
    • Can be run from landmark output, but needs to be integrated into the interface to avoid duplicated input. Steve will work on this.
    • Algorithm runs but does not complete correctly. Nadya will work on this.
  • Steve and Nadya reviewed the iterative algorithm and generated design ideas for interface
  1. pick fixed and moving0, and define landmarks
    1. run algorithm to get movingN and landmarksN
    2. adjust new landmarks to improve match
    3. repeat to convergence
  2. review moving volumes and landmarks as multivolume

Delivery Mechanism

This work will be delivered to the NA-MIC Kit as a Slicer module, ultimately integrated into the slicer core