Distribution modeling

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Key Investigators

Anuja Sharma, Guido Gerig

Project Description


  • Evaluate the ability of regression methods utilizing distribution-valued measurements to differentiate between healthy controls and patients with pathology.

Approach, Plan

  • Model probability distributions along DTI fiber tracts instead of scalar summary measurements to create a tract profile (e.g. cross-sectional averages).
  • Our spatiotemporal modeling method utilizes these distribution-valued data to create growth trajectories such that the complete probability distribution is estimated continuously in space and time.
  • Using these methods, we can estimate a spatiotemporal growth trajectory for the healthy infant population. We then compare our method's ability to detect clinical differences in infants with Krabbe's disease in reference to a control population.


  • We found that our method had better sensitivity towards finding differences in growth trajectories.
  • We could find statistically significant differences in scenarios where the differences were small enough to be missed by conventional methods.